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Products and Services |
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| Buy Chemicals | Biological Research Tools | Building Blocks |
| Catalogs for downloading (updated April, 2008) | Custom Synthesis Services | |
| Discounts, Rebates, and Bargains | Find Focus Synthesis Products Online | Quality Control |
| Online Structure Searching | Screening Compounds | Synthon Design Services |
Online Product Category Catalogs (Click to see structures and prices) |
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Acetals Aldehydes Alkoxyamines Alkynes Amines Anilines and Arylamines Aryl Bromides and Iodides Bargains Biological Research Tools Boronic Acids and Pinacolates Bromoketones Carboxylic Acids Carboxylic Esters Cheminformatic Gap Fillers | Cyclobutanes Difluoromethylorganics Drug Raw Materials and Analogs Exotic Heterocycles Heterocycles (5-membered ring) Heterocycles (7-membered ring) Heterocycles (Bicyclic, Tricyclic) Heterocyclic Bromides Imidazolones Imidazopyridines Isothiazole Derivatives Leadlike Rule of 3 (RubyRO3) Miscellaneous NEW JULY 2008 | NEW JUNE 2008 NEW MAR APR 08 NEW MAY2008 Nitriles Piperidines Pyridine Derivatives Rarest Molecules (RubySynthons) Rare Heterocycles (RubyScaffolds) Rare Shapes (RubyShapes) Spiroheterocycles Sulfonyl Chlorides Very Small Molecules (FW<150) |
Locating Focus Synthesis Product Structures and PricesThere are a number of ways of locating focus product chemical structures and prices:
Building BlocksThere are over 560 Focus Synthesis building blocks in stock as of
June, 2008. More than 190 of these stock items are the
high-value synthons containing rare and unique substructures.® The building block catalog will be continually upgraded by adding new molecules to the catalog on a monthly basis. Stock availability ranges from 0.2 to 1000 grams. Most Focus Synthesis building blocks can be scaled up to as much as 10 kilograms on request. Click on the following links for overviews concerning these Focus building block product lines: Rare and Unique Substructure Classes, "Rule of Three" Building Blocks, Cheminformatic Gap Fillers, and Atom Scanning Tools. In-stock synthons and building blocks in the Focus Synthesis catalog include molecules containing these exotic heterocycles: benzooxepine, benzooxazine, benzothiadiazole, cinnoline, diazocane, dioxabicylcooctane, imidazolone, pyranothiazole, ethylenedithioindane, imidazopyrazine, imidazopyridine, imidazopyrimidine, imidazothiazole, isothiazole, isothiazolopyridine, pyrazolopyrimidine, pyridopyrazine, pyridopyrimidine, and thiadiazinane. Focus Synthesis offers research chemicals with the following useful and unusual functional groups: alkoxyamine, oxetanyl, ethoxycarbonyldifluoromethoxy, and dioxolanemethoxy. Focus also offers molecules with distinctive regiochemistry, such as 7-Bromo-benzo[b]thiophene (FS001166), 8-Bromo-imidazo[1,2-a]pyridine (FS000684), 7-Bromo-2,4-diaminoquinazoline (FS002017), 6-Bromoisoquinoline (FS002008), and 6-Bromoquinazoline (FS002067). These intermediates provide the combinatorial chemist with precursors for highly diverse libraries containing numerous patentable scaffolds and exhibiting superior property space coverage. Synthon Design ServicesFocus Synthesis now offers confidential building block design services to help meet your specific requirements for diversity and property space coverage in medicinal and high-throughput chemistry. The synthetic intermediates made through Synthon Design ServicesSM, known as SDS Building BlocksTM, will be substantially distinct from commercially available building blocks. The differentiation from commercial building blocks will be based on Rare and Unique SubstructuresTM, ultrarare substructures (RubySynthonsTM), exotic heterocycles (RubyScaffoldsTM), rare molecular graphs (RubyShapesTM), as well as Cheminformatic Gap FillersTM. More detailed descriptions of the corresponding catalog products can be found on the About Page.
A more focused service, also requiring the protection of a nondisclosure agreement, would provide the most useful diversity by identify building blocks that are distinct relative to your corporate compound collection as well as commercial databases. SDS Building BlocksTM will be designed to meet other specifications that you define, such as PSA, ClogP, FW, EA, type of functionality, ring system, complexity, rule-of-five, etc. Care will be taken to ensure synthetic accessibility. If warranted, in-house trial runs of key synthetic steps can be carried out in house on small (~100 mg) scales to better determine feasibility. In-house custom synthesis of larger quantities (up to 20 grams) by Focus Synthesis will be provided as an option. Part of the design cost will be discounted if you choose Focus Synthesis to synthesize the SDS blocksTM. Synthon Design Services TM will be available on a straightforward fee-for-service bases, and all rights to the structures and uses of SDS Building BlocksTM will pass to your organization, within a period of exclusivity ranging from 3 months to 2 years. Exclusivity can be limited to individual molecular structures or extended to the entire substructure class or cheminformatic property space cell. If structure-based design services are required, these can be provided through the established partnership between Focus Synthesis LLC and Sapient Discovery LLC. Sapient Discovery is a privately held drug discovery services company employing proprietary 3-D structure and virtual screening technologies to accelerate lead molecule identification and optimization for novel and validated therapeutic protein targets. Sapient Discovery can design focused libraries using rare synthons from Focus Synthesis as the starting point, carry out rapid in silico ranking of these virtual libraries, predict and rank order potency by means of free-energy calculation and rank binding affinity for protein targets. Sapient Discovery also provides complete protein expression, purification, and x-ray crystallography services for protein and novel protein/ligand complex structure determination. X-ray crystallography is used to validate and guide medicinal chemistry efforts for drug discovery and optimization. This partnership provides you the ability to improve the strength and breadth of your IP position by expanding on unique hits and leads identified in libraries that combine the power of Sapient Discovery and Focus Synthesis technologies. Screening CompoundsWhile maintaining a strong emphasis on building blocks in quantities suitable for small scale synthetic chemistry (100mg to 20g), many products offered by Focus Synthesis will be sold in 10 mg quantities to enable their use in high-through-put screening. Biological Research Tools
Focus Synthesis has added a number of small molecules that are useful for biological or biochemical research. These include:
Custom Synthesis ServicesFocus Synthesis has recently (April, 2006) established its own laboratory space in San Diego, California. The new synthetic laboratory is suitable for small scale (1 mg to 20 gram) synthesis of exclusive custom synthesis items and Special Order catalog items. Focus Synthesis can now supply most Special Order catalog items with a 1 to 8 week lead time.
Supplementing these in-house capabilities, Focus Synthesis will continue to use its established relationships with a world-wide network of suppliers to identify the best match for your requirements for custom synthesis projects. Focus Synthesis will determine which supplier is most appropriate in terms of synthetic capabilities, timing, price, and desired level of purity. Focus will add value by taking care of synthetic route design and follow-up with the synthetic laboratory to ensure timely delivery of product with the desired specifications, and ensuring that all of the required analytical and spectroscopic work is done. Multiple sourcing will be available if needed in order to ensure continued availability of the desired compound as your project progresses. In addition to a very wide variety of methods for synthesis of heterocyclic compounds, polyfunctional scaffolds and other druggable synthons, specialized services such as solid phase peptide synthesis are now available through Focus Synthesis. Quality ControlAll Focus Synthesis catalog items are > 95% pure unless otherwise indicated. Analysis will always include HNMR and either HPLC, GC, or mass spec. Additional data (13CNMR, FNMR, IR, LC/MS, TLC, melting point) will be included when warranted. Analytical data, spectroscopic data and Material Safety Data Sheets will be made available on request for all Focus Synthesis products currently or formerly in stock. Discounts and Rebates
Focus Synthesis offers a number of incentives that can help you to reduce costs, as outlined below. These incentives are available for a limited time only, and may be discontinued without notice. Please inquire for additional details.
Catalogs for Downloading (Updated Jan 21, 2008)Download the Focus Synthesis catalog in the format of your choice:
Empirical Formula Listing(Updated May 2007)*Note concerning Special Order chemicals: these are made to order, typically in 1 to 8 weeks. The typical minimum order size is 1 to 5 grams. |
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