Locating Focus Synthesis Product Structures and Prices

There are a number of ways of locating focus product chemical structures and prices:

1. BY 2D STRUCTURE OR SUBSTRUCTURE: Click here to search focus synthesis product molecules by structure or substructure^®.
   
2. BY SUBCATALOG: Click on the substructure catalogs along the left side of this page. These include categories such as aryl bromides and iodides, boronic acids and esters, pyridines, isothiazoles, alkoxyamines, imidazopyridines, cyclobutanes, and rare and unique substructure^® classes.
   
3. DOWNLOADABLE CATALOGS: Click here for the link to an electronic catalog (Isis Base [.db and .sdf), .xls and .pdf formats) updated on January 12, 2010.
4. ONLINE SEARCH: Enter the catalog number, CASRN, MFCD#, chemical name, or part of the chemical name in the box at the top of this page, and press "search catalog".
   

Building Blocks

As of March, 2010, customers can buy chemicals from over 750 stock items, including over 550 building blocks and synthons. More than 240 of these stock items are the high-value synthons containing Rare and Unique Substructures^®. The building block catalog will be continually upgraded by adding new molecules with Rare and Unique Substructures^® to the catalog each monthly basis. (Click here to see structures and prices for the most recent additions to the catalog). Stock availability ranges from 10mg to 1000 grams. Many Focus Synthesis building blocks can be scaled up to multikilogram quantities on request--Focus Synthesis has filled orders as large as 20 kilograms.

Click on the following links for overviews concerning these Focus building block product lines: Rare and Unique Substructure Classes, "Rule of Three" Building Blocks, Cheminformatic Gap Fillers, and Atom Scanning Tools.

Focus Synthesis is particularly strong in the following areas: Suzuki reaction substrates (boronic acids and aryl bromides). Focus also offers molecules with distinctive regiochemistry, such as 6-Bromo-benzo[b]thiophene (FS002042), 8-Bromo-imidazo[1,2-a]pyridine (FS000684), 6-Bromoisoquinoline (FS002008), and 6-Bromoquinazoline (FS002067). These intermediates provide combinatorial and medicinal chemists with precursors for highly diverse libraries and compound collections containing numerous patentable scaffolds and exhibiting superior property space coverage.

Screening Compounds

While maintaining a strong emphasis on building blocks in quantities suitable for small scale synthetic chemistry (100mg to 20g), many products offered by Focus Synthesis will be sold in 10 mg quantities to enable their use in high-through-put screening.

Biological Research Tools

Focus Synthesis has added a number of small molecules that are useful for Life Science research. These include:

1. Aminoalkylsulfonamides that inhibit PKB and other kinases (FS002230, FS200081, FS002244), and close analogs (FS002212, FS002214, FS002216, FS002240, FS002224, FS002225,FS002227, FS002232,FS002241,FS002243,FS002246,FS002247).
2. Analogs of the ROCK (Rho-associated protein kinase) inhibitor Y-27632 (FS040237-FS040247)
3. Tyrosine kinase inhibitors with diarylamine scaffolds such as gefitinib (FS200036), lapatinib (FS200039), and nilotinib (FS200045).
4. Advanced Glycosylation Endproducts (AGEs), useful for understanding aging-related protein modification, include CML (FS810003), and pentosidine (FS810006).
5. Organoselenium compounds useful as free-radical scavenging antioxidants (FS000075- FS000079).

Custom Synthesis Services

Focus Synthesis has had its own laboratory space in San Diego, California since 2006. The new synthetic laboratory is suitable for small scale (1 mg to 20 gram) synthesis of exclusive custom synthesis items and Special Order (nonexclusive custom) catalog items. Our in-house strengths include distinctive molecules with the following functionalities and moieties: boronic acid (especially fluorinated arylboronics), alkoxyamine, ethynyl, vinyl, bromo, iodo, bromoketone, difluoromethyl and difluoromethoxy. Our in-house laboratory is also adept at providing unsual heterocyclic building blocks dervied from azetidine, isatin, imidazolone, imidazopyridine, pyridopyrazine, isothiazole, isoquinoline, quinazoline, benzothiophene and others. Focus Synthesis can supply many Special Order catalog items with a 1 to 4 week lead time.

Supplementing these in-house capabilities, Focus Synthesis will continue to use its established relationships with a world-wide network of suppliers to identify the best match for your requirements for custom synthesis projects. Focus Synthesis will determine which supplier is most appropriate in terms of synthetic capabilities, timing, price, and desired level of purity. Focus will add value by taking care of synthetic route design and follow-up with the synthetic laboratory to ensure timely delivery of product with the desired specifications, and ensuring that all of the required analytical and spectroscopic work is done.

Focus Synthesis custom outsourcing emphasizes small organic molecules made on scales from 1 mg to 1 kg under non-GMP conditions. However, Focus can also arrange outsourcing of other services, including pilot plant scale synthesis (1-1000 kg), GMP synthesis, and synthesis associated with generation of a DMF (drug master file). Focus Synthesis has filled orders ranging from 10 mg to 20 kg.

Quality Control

All Focus Synthesis catalog items are > 95% pure unless otherwise indicated. Analysis will always include HNMR and either HPLC, GC, or mass spec. Additional data (13CNMR, FNMR, IR, LC/MS, TLC, melting point) will be included when warranted. Analytical data, spectroscopic data and Material Safety Data Sheets will be made available on request for all Focus Synthesis products currently or formerly in stock.

Discounts and Rebates

Focus Synthesis offers a number of incentives that can help you to reduce costs, as outlined below. These incentives are available for a limited time only, and may be discontinued without notice. Please inquire for additional details.

• The Bargains subcatalog includes popular items at prices that are competitive with other catalog, and rare items priced at less than $99 per gram that are not found in other chemical catalogs.

  Click here to see the Bargains subcatalog, including chemical structures.

• The "Less than $500" catalog is provided to assist customers who have a $500 limit on purchases.
• Generous volume discounting is available for most Special Order compounds and many stock items.

Synthon Design Services

Focus Synthesis now offers confidential building block design services to help meet your specific requirements for diversity and property space coverage in medicinal and high-throughput chemistry. The synthetic intermediates made through Synthon Design Services^SM, known as SDS Building Blocks^TM, will be substantially distinct from commercially available building blocks. The differentiation from commercial building blocks will be based on Rare and Unique Substructures^TM, ultrarare substructures (RubySynthons^TM), exotic heterocycles (RubyScaffolds^TM), rare molecular graphs (RubyShapes^TM), as well as Cheminformatic Gap Fillers^TM. More detailed descriptions of the corresponding catalog products can be found on the About Page.

A more focused service, also requiring the protection of a nondisclosure agreement, would provide the most useful diversity by identify building blocks that are distinct relative to your corporate compound collection as well as commercial databases. SDS Building Blocks^TM will be designed to meet other specifications that you define, such as PSA, ClogP, FW, EA, type of functionality, ring system, complexity, rule-of-five, etc.

Care will be taken to ensure synthetic accessibility. If warranted, in-house trial runs of key synthetic steps can be carried out in house on small (~100 mg) scales to better determine feasibility. In-house custom synthesis of larger quantities (up to 20 grams) by Focus Synthesis will be provided as an option. Part of the design cost will be discounted if you choose Focus Synthesis to synthesize the SDS blocks^TM.

Catalogs for Downloading (Updated March 2, 2010)

Download the Focus Synthesis catalog in the format of your choice:

Complete Catalogs

• Complete catalog (March 2, 2010) in .pdf format
• Complete catalog (March 2, 2010) in .sdf format

Items In Stock

• In Stock items only (March 2, 2010) in Microsoft Excel (.xls) format
• In Stock items only (March 2, 2010) in .pdf format
• In Stock items only (March 2, 2010) in .sdf format
• In Stock items only (March 2, 2010) in .db format (compressed file downloadable in .zip format)

*Note concerning Special Order chemicals: these are made to order, typically in 1 to 8 weeks. The minimum order size is usually 1 to 5 grams.