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Products and Services |
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Online Product Category Catalogs (Click to see structures and prices) |
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AAAIn Stock Acetals Aldehydes Alkenes Alkoxyamines Alkyl Bromides Alkynes Amines Anilines and Arylamines APIs Aryl Bromides and Iodides Azetidines Bargains Bicyclic and Polycyclic Heterocycles Biological Research Tools Boc-Amino-Amines Boronic Acids and Pinacolates Bromoketones | Carboxylic Acids Cheminformatic Gap Fillers Cyclobutanes Difluoromethylorganics Drug Raw Materials and Analogs Esters Exotic Heterocycles (RubyScaffolds) FEATURED MOLECULES Heterocycles (5-membered ring) Heterocycles (7-membered ring) Heterocyclic Bromides Hydrazines Imidazolones Imidazopyridines Isocyanates Isothiazole Derivatives Leadlike Rule of 3 (RubyRO3) Less Than $500 | Miscellaneous NEW JAN FEB 2010 NEW JULY AUG 2009 NEW NOV DEC 2009 NEW SEPT OCT 2009 Nitriles Phenols Piperidines Pyrazoles Pyridazines Pyridines Rarest Molecules (RubySynthons) Rare Shapes (RubyShapes) Screening Compounds Spiroheterocycles Sulfonamides Sulfonyl Chlorides Very Small Molecules (FW<150) | |
Links to Subsections |
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| Biological Research Tools | Custom Synthesis Services | Online Structure Searching | |
| Building Blocks, Scaffolds and Synthons | Discounts, Rebates, and Bargains | Quality Control | |
| Buy Chemicals | Find Focus Synthesis Products Online | Screening Compounds | |
| Catalogs for downloading | Synthon Design Services | ||
Locating Focus Synthesis Product Structures and PricesThere are a number of ways of locating focus product chemical structures and prices:
Building BlocksAs of March, 2010, customers can buy chemicals from over 750 stock items, including over 550 building blocks and synthons. More than 240 of these stock items are the
high-value synthons containing Rare and Unique Substructures®. The building block catalog will be continually upgraded by adding new molecules with Rare and Unique Substructures® to the catalog each monthly basis. (Click here to see structures and prices for the most recent additions to the catalog). Stock availability ranges from 10mg to 1000 grams. Many Focus Synthesis building blocks can be scaled up to multikilogram quantities on request--Focus Synthesis has filled orders as large as 20 kilograms. Click on the following links for overviews concerning these Focus building block product lines: Rare and Unique Substructure Classes, "Rule of Three" Building Blocks, Cheminformatic Gap Fillers, and Atom Scanning Tools. Focus Synthesis is particularly strong in the following areas: Suzuki reaction substrates (boronic acids and aryl bromides). Focus also offers molecules with distinctive regiochemistry, such as 6-Bromo-benzo[b]thiophene (FS002042), 8-Bromo-imidazo[1,2-a]pyridine (FS000684), 6-Bromoisoquinoline (FS002008), and 6-Bromoquinazoline (FS002067). These intermediates provide combinatorial and medicinal chemists with precursors for highly diverse libraries and compound collections containing numerous patentable scaffolds and exhibiting superior property space coverage. Screening CompoundsWhile maintaining a strong emphasis on building blocks in quantities suitable for small scale synthetic chemistry (100mg to 20g), many products offered by Focus Synthesis will be sold in 10 mg quantities to enable their use in high-through-put screening. Biological Research Tools
Focus Synthesis has added a number of small molecules that are useful for Life Science research. These include:
Custom Synthesis ServicesFocus Synthesis has had its own laboratory space in San Diego, California since 2006. The new synthetic laboratory is suitable for small scale (1 mg to 20 gram) synthesis of exclusive custom synthesis items and Special Order (nonexclusive custom) catalog items. Our in-house strengths include distinctive molecules with the following functionalities and moieties: boronic acid (especially fluorinated arylboronics), alkoxyamine, ethynyl, vinyl, bromo, iodo, bromoketone, difluoromethyl and difluoromethoxy. Our in-house laboratory is also adept at providing unsual heterocyclic building blocks dervied from azetidine, isatin, imidazolone, imidazopyridine, pyridopyrazine, isothiazole, isoquinoline, quinazoline, benzothiophene and others. Focus Synthesis can supply many Special Order catalog items with a 1 to 4 week lead time.
Supplementing these in-house capabilities, Focus Synthesis will continue to use its established relationships with a world-wide network of suppliers to identify the best match for your requirements for custom synthesis projects. Focus Synthesis will determine which supplier is most appropriate in terms of synthetic capabilities, timing, price, and desired level of purity. Focus will add value by taking care of synthetic route design and follow-up with the synthetic laboratory to ensure timely delivery of product with the desired specifications, and ensuring that all of the required analytical and spectroscopic work is done. Quality ControlAll Focus Synthesis catalog items are > 95% pure unless otherwise indicated. Analysis will always include HNMR and either HPLC, GC, or mass spec. Additional data (13CNMR, FNMR, IR, LC/MS, TLC, melting point) will be included when warranted. Analytical data, spectroscopic data and Material Safety Data Sheets will be made available on request for all Focus Synthesis products currently or formerly in stock. Discounts and Rebates
Focus Synthesis offers a number of incentives that can help you to reduce costs, as outlined below. These incentives are available for a limited time only, and may be discontinued without notice. Please inquire for additional details.
Synthon Design ServicesFocus Synthesis now offers confidential building block design services to help meet your specific requirements for diversity and property space coverage in medicinal and high-throughput chemistry. The synthetic intermediates made through Synthon Design ServicesSM, known as SDS Building BlocksTM, will be substantially distinct from commercially available building blocks. The differentiation from commercial building blocks will be based on Rare and Unique SubstructuresTM, ultrarare substructures (RubySynthonsTM), exotic heterocycles (RubyScaffoldsTM), rare molecular graphs (RubyShapesTM), as well as Cheminformatic Gap FillersTM. More detailed descriptions of the corresponding catalog products can be found on the About Page.
A more focused service, also requiring the protection of a nondisclosure agreement, would provide the most useful diversity by identify building blocks that are distinct relative to your corporate compound collection as well as commercial databases. SDS Building BlocksTM will be designed to meet other specifications that you define, such as PSA, ClogP, FW, EA, type of functionality, ring system, complexity, rule-of-five, etc. Care will be taken to ensure synthetic accessibility. If warranted, in-house trial runs of key synthetic steps can be carried out in house on small (~100 mg) scales to better determine feasibility. In-house custom synthesis of larger quantities (up to 20 grams) by Focus Synthesis will be provided as an option. Part of the design cost will be discounted if you choose Focus Synthesis to synthesize the SDS blocksTM. Catalogs for Downloading (Updated March 2, 2010)Download the Focus Synthesis catalog in the format of your choice: Complete CatalogsItems In Stock*Note concerning Special Order chemicals: these are made to order, typically in 1 to 8 weeks. The minimum order size is usually 1 to 5 grams. |
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