Locating Focus Synthesis Product Structures and Prices

There are a number of ways of locating focus product chemical structures and prices:

1. BY 2D STRUCTURE OR SUBSTRUCTURE: Click here to access the structure-searchable catalog, based on rapid search technology from eMolecules^®.
   
2. BY SUBCATALOG: Click on the substructure catalogs along the left side of this page. These include categories such as aryl bromides and iodides, boronic acids and esters, pyridines, isothiazoles, alkoxyamines, imidazopyridines, cyclobutanes, and rare and unique substructure^® classes.
   
3. DOWNLOADABLE CATALOGS: Click here for the link to an electronic catalog (Isis Base [.db and .sdf), .xls and .pdf formats) updated on Jan 21, 2008.
4. PRINT CATALOG: Order a print or CD-Rom catalog (Click here for the Contact Us page).
   
5. ONLINE SEARCH: Enter the catalog number, chemical name, or part of the chemical name in the box at the top of this page, and press "search catalog".
   
6. BY CAS NUMBER: Searches by entire CAS number (CASRN) can now be performed using the search box at the top of this page.
   
7. Click here to search for Focus Synthesis in-stock items by empirical formula.
   
8. Click here to learn about custom synthesis services provided by Focus Synthesis.

Building Blocks

There are over 560 Focus Synthesis building blocks in stock as of June, 2008. More than 190 of these stock items are the high-value synthons containing rare and unique substructures.^® The building block catalog will be continually upgraded by adding new molecules to the catalog on a monthly basis. Stock availability ranges from 0.2 to 1000 grams. Most Focus Synthesis building blocks can be scaled up to as much as 10 kilograms on request.

Click on the following links for overviews concerning these Focus building block product lines: Rare and Unique Substructure Classes, "Rule of Three" Building Blocks, Cheminformatic Gap Fillers, and Atom Scanning Tools.

In-stock synthons and building blocks in the Focus Synthesis catalog include molecules containing these exotic heterocycles: benzooxepine, benzooxazine, benzothiadiazole, cinnoline, diazocane, dioxabicylcooctane, imidazolone, pyranothiazole, ethylenedithioindane, imidazopyrazine, imidazopyridine, imidazopyrimidine, imidazothiazole, isothiazole, isothiazolopyridine, pyrazolopyrimidine, pyridopyrazine, pyridopyrimidine, and thiadiazinane. Focus Synthesis offers research chemicals with the following useful and unusual functional groups: alkoxyamine, oxetanyl, ethoxycarbonyldifluoromethoxy, and dioxolanemethoxy. Focus also offers molecules with distinctive regiochemistry, such as 7-Bromo-benzo[b]thiophene (FS001166), 8-Bromo-imidazo[1,2-a]pyridine (FS000684), 7-Bromo-2,4-diaminoquinazoline (FS002017), 6-Bromoisoquinoline (FS002008), and 6-Bromoquinazoline (FS002067). These intermediates provide the combinatorial chemist with precursors for highly diverse libraries containing numerous patentable scaffolds and exhibiting superior property space coverage.

Synthon Design Services

Focus Synthesis now offers confidential building block design services to help meet your specific requirements for diversity and property space coverage in medicinal and high-throughput chemistry. The synthetic intermediates made through Synthon Design Services^SM, known as SDS Building Blocks^TM, will be substantially distinct from commercially available building blocks. The differentiation from commercial building blocks will be based on Rare and Unique Substructures^TM, ultrarare substructures (RubySynthons^TM), exotic heterocycles (RubyScaffolds^TM), rare molecular graphs (RubyShapes^TM), as well as Cheminformatic Gap Fillers^TM. More detailed descriptions of the corresponding catalog products can be found on the About Page.

A more focused service, also requiring the protection of a nondisclosure agreement, would provide the most useful diversity by identify building blocks that are distinct relative to your corporate compound collection as well as commercial databases. SDS Building Blocks^TM will be designed to meet other specifications that you define, such as PSA, ClogP, FW, EA, type of functionality, ring system, complexity, rule-of-five, etc.

Care will be taken to ensure synthetic accessibility. If warranted, in-house trial runs of key synthetic steps can be carried out in house on small (~100 mg) scales to better determine feasibility. In-house custom synthesis of larger quantities (up to 20 grams) by Focus Synthesis will be provided as an option. Part of the design cost will be discounted if you choose Focus Synthesis to synthesize the SDS blocks^TM.

Synthon Design Services ^TM will be available on a straightforward fee-for-service bases, and all rights to the structures and uses of SDS Building Blocks^TM will pass to your organization, within a period of exclusivity ranging from 3 months to 2 years. Exclusivity can be limited to individual molecular structures or extended to the entire substructure class or cheminformatic property space cell.

If structure-based design services are required, these can be provided through the established partnership between Focus Synthesis LLC and Sapient Discovery LLC. Sapient Discovery is a privately held drug discovery services company employing proprietary 3-D structure and virtual screening technologies to accelerate lead molecule identification and optimization for novel and validated therapeutic protein targets. Sapient Discovery can design focused libraries using rare synthons from Focus Synthesis as the starting point, carry out rapid in silico ranking of these virtual libraries, predict and rank order potency by means of free-energy calculation and rank binding affinity for protein targets. Sapient Discovery also provides complete protein expression, purification, and x-ray crystallography services for protein and novel protein/ligand complex structure determination. X-ray crystallography is used to validate and guide medicinal chemistry efforts for drug discovery and optimization. This partnership provides you the ability to improve the strength and breadth of your IP position by expanding on unique hits and leads identified in libraries that combine the power of Sapient Discovery and Focus Synthesis technologies.

Screening Compounds

While maintaining a strong emphasis on building blocks in quantities suitable for small scale synthetic chemistry (100mg to 20g), many products offered by Focus Synthesis will be sold in 10 mg quantities to enable their use in high-through-put screening.

Biological Research Tools

Focus Synthesis has added a number of small molecules that are useful for biological or biochemical research. These include:

1. Aminoalkylsulfonamides that are known to inhibit PKB and other kinases (FS002230 and FS002244),or are closely related in structure to such inhibitors (FS002212, FS002214, FS002216, FS002240). These can be particularly useful as controls for kinase inhibitor discovery programs.
2. Advanced Glycosylation Endproducts (AGEs), which are useful for understanding aging and diabetes-related protein modification. AGEs in the Focus Synthesis catalog include CML (FS810003), d4-CML (FS810004), argpyrimidine (FS810001), and MRX (FS810002).
3. Organoselenium compounds useful as free-radical scavenging antioxidants (FS000075 through FS000079).

Custom Synthesis Services

Focus Synthesis has recently (April, 2006) established its own laboratory space in San Diego, California. The new synthetic laboratory is suitable for small scale (1 mg to 20 gram) synthesis of exclusive custom synthesis items and Special Order catalog items. Focus Synthesis can now supply most Special Order catalog items with a 1 to 8 week lead time.

Supplementing these in-house capabilities, Focus Synthesis will continue to use its established relationships with a world-wide network of suppliers to identify the best match for your requirements for custom synthesis projects. Focus Synthesis will determine which supplier is most appropriate in terms of synthetic capabilities, timing, price, and desired level of purity. Focus will add value by taking care of synthetic route design and follow-up with the synthetic laboratory to ensure timely delivery of product with the desired specifications, and ensuring that all of the required analytical and spectroscopic work is done. Multiple sourcing will be available if needed in order to ensure continued availability of the desired compound as your project progresses. In addition to a very wide variety of methods for synthesis of heterocyclic compounds, polyfunctional scaffolds and other druggable synthons, specialized services such as solid phase peptide synthesis are now available through Focus Synthesis.

Focus Synthesis custom outsourcing emphasizes small organic molecules made on scales from 1 mg to 1 kg under non-GMP conditions. However, Focus can also arrange outsourcing of other services, including pilot plant scale synthesis (10-1000 kg), GMP synthesis, and synthesis associated with generation of a DMF (drug master file).

Quality Control

All Focus Synthesis catalog items are > 95% pure unless otherwise indicated. Analysis will always include HNMR and either HPLC, GC, or mass spec. Additional data (13CNMR, FNMR, IR, LC/MS, TLC, melting point) will be included when warranted. Analytical data, spectroscopic data and Material Safety Data Sheets will be made available on request for all Focus Synthesis products currently or formerly in stock.

Discounts and Rebates

Focus Synthesis offers a number of incentives that can help you to reduce costs, as outlined below. These incentives are available for a limited time only, and may be discontinued without notice. Please inquire for additional details.

• The Bargains subcatalog includes popular items at prices that are competitive with other catalog, and rare items priced at less than $99 per gram that are not found in other chemical catalogs. Click here to see the Bargains subcatalog, including chemical structures.
• Focus Synthesis provides rebates for referals of new customers. Once Focus has received $1000 or more in payments from a new customer that you have introduced to the company, both of you will receive a $50 rebate.
• When orders exceed $5000 total list price in any month (for In Stock items), a credit toward future orders will be provided upon receipt of payment. Please inquire.
• Generous volume discounting is available for most Special Order compounds and many stock items.

Catalogs for Downloading (Updated Jan 21, 2008)

Download the Focus Synthesis catalog in the format of your choice:

• In Stock items only (Jan 21, 2008) in Isis Base database(.db) format
• Complete catalog in Isis Base molfile (.sdf) format
• Complete catalog in Microsoft Excel (.xls) format
• Complete catalog in .pdf format

Empirical Formula Listing(Updated May 2007)

• Empirical formula listing for Focus Synthesis stock items (click here for html page)

*Note concerning Special Order chemicals: these are made to order, typically in 1 to 8 weeks. The typical minimum order size is 1 to 5 grams.