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Products and Services
Streamline Drug Discovery with Rare Substructures
Focus Synthesis is chemical manufacturer and distributor with particular strength in synthons and
building blocks with rare substructures and
functional groups such as aryl bromides,
boronic acids and
boron pinacolates,
(suitable for Suzuki coupling).
Other strengths include functional groups such as
aryl iodides
and, terminal alkynes
for Sonogashira coupling,
alkoxyamines,
and bromoketones.
As a chemical manufacturer, Focus Synthesis is also carries distinctive heterocycles, including derivatives of
azetidine, ,
pyridazine, and
isothiazole.
To improve your i.p position and explore uncharted regions of chemical space, purchase
exotic heterocycles
such as diazocane, thiadiazinane, oxazepane, oxa-aza-spirooctane, isothiazolo-pyridine, diaza-bicyclooctane, and
thieno-pyridazine. Focus Synthesis carries unusual
biological research tools such as kinase inhibitors,
APIs, and other life science chemicals.
Our in-house and outsourced custom organic synthesis services are detailed
here.
Online Product Category Catalogs
(Click to see structures and prices)Finding Focus Synthesis Product Structures and Prices
There are a number of ways of locating focus product chemical structures and prices:
- BY 2D STRUCTURE OR SUBSTRUCTURE SEARCH: Click here to search focus synthesis product molecules by structure or substructure®.
- BY SUBCATALOG: Click here to see our online category catalogs, including Featured Products, Azetidines, Boronic Acids and Pinacolates, and more.
- BY DOWNLOADABLE CATALOGS: Click here for the link to an electronic catalog (Isis Base [.db and .sdf), .xls and .pdf formats) updated on July 22, 2010.
- BY MAIL CATALOG: Order a print catalog (in-stock items) or CD-rom catalog by mail by clicking here.
Custom Organic Synthesis Services
Since 2006, Focus Synthesis has been a contract research organization/chemical manufacturer. Our laboratory space in San Diego, California is used for custom medicinal chemistry and synthesis of rare chemicals for our catalog. The new synthetic laboratory is suitable for small scale (1 mg to 50 grams) synthesis of exclusive custom synthesis items and Special Order (nonexclusive custom) catalog items. Our in-house strengths include distinctive molecules with the following functional groups and side chains: aryl bromide and boronic acid (especially heterocycles) for Suzuki-Miyaura cross-coupling, alkoxyamine, aryl iodide, alkyne (for Sonogashira cross-coupling), bromoketone, sulfonyl chloride, difluoromethoxy, and others. Our in-house laboratory is particularly strong in unsual heterocyclic building blocks and synthons derived from azetidine, isothiazole, oxetane, pyridine, pyridazine, and a wide variety of exotic hetercycles.
Supplementing these in-house capabilities, Focus Synthesis will continue to use its established relationships with a world-wide network of suppliers to identify the best match for your requirements for custom synthesis projects. Focus Synthesis will determine which supplier is most appropriate in terms of synthetic capabilities, timing, price, and desired level of purity. Focus will add value by taking care of synthetic route design and follow-up with the synthetic laboratory to ensure timely delivery of product with the desired specifications, and ensuring that all of the required analytical and spectroscopic work is done.
Focus Synthesis custom outsourcing emphasizes small organic molecules made on scales from 1 mg to 1 kg under non-GMP conditions. However, Focus Synthesis has also arranged outsourcing of other services, including pilot plant scale synthesis up to 100kg.
Quality Control
All Focus Synthesis catalog items are > 95% pure unless otherwise indicated. Analysis will always include HNMR and either HPLC, GC, or mass spec. Additional data (13CNMR, FNMR, IR, LC/MS, TLC, melting point) will be included when warranted. Analytical data, spectroscopic data and Material Safety Data Sheets will be made available on request for all Focus Synthesis products currently or formerly in stock.
Building Blocks, Synthons and Precursors
As of June, 2010, customers can buy chemicals from over 800 chemicals in stock, mostly building blocks and synthons.
More than 290 of these stock items are the high-value synthons containing Rare and Unique Substructures®.
As a chemical distributor, Focus Synthesis emphasizes distinctiveness and drugability over number of different products
because our main goal is to help pharmaceutical and biotechnology companies find the right molecule and design better
drugs. The chemical building block catalog will be continually upgraded by adding new molecules with Rare Substructures
to the catalog each month, and by removing molecules from the Rare and Unique Substructures when needed every 6 months.
(Click here to see
structures and prices for the most recent additions to the catalog). Stock availability ranges from 10mg to 1000 grams.
Many Focus Synthesis building blocks can be scaled up to multikilogram quantities on request--Focus Synthesis has filled
orders as large as 225 kilograms.
Click on the following links for overviews concerning these Focus building block product lines:
Rare and Unique Substructure Classes,
"Rule of Three" Building Blocks, and
Cheminformatic Gap Fillers.
Focus Synthesis is particularly strong in the following areas: 1)Suzuki reaction substrates (boronic acids and aryl
bromides), 2) Derivatives of isothiazole, azetidine, pyridine, pyridazine, and numerous exotic heterocycles.
3) Alkoxyamines, bromoketones, sulfonyl chlorides, difluoromethyl and difluroethyl molecules, and (4) molecules with
unusual regiochemistry, such as 6-Bromo-benzo[b]thiophene (FS002042), 8-Bromo-imidazo[1,2-a]pyridine (FS000684),
6-Bromoisoquinoline (FS002008), and 6-Bromoquinazoline (FS002067). These intermediates provide combinatorial and
medicinal chemists with precursors for highly diverse libraries and compound collections containing numerous patentable
scaffolds and exhibiting superior property space coverage. These molecule types are represented in the
Featured Molecule online catalog.
Screening Compounds
While maintaining a strong emphasis on building blocks in quantities suitable for small scale synthetic chemistry (100mg to 20g), many products offered by Focus Synthesis will be sold in 10 mg quantities to enable their use in high-through-put screening.
Biological Research Tools
Focus Synthesis has added a number of small molecules that are useful for Life Science research. These include:
- Aminoalkylsulfonamides that inhibit PKB and other kinases (FS002230, FS200081, FS002244), and close analogs (FS002212, FS002214, FS002216, FS002240, FS002224, FS002225,FS002227, FS002232,FS002241,FS002243,FS002246,FS002247).
- Analogs of the ROCK (Rho-associated protein kinase) inhibitor Y-27632 (FS040237-FS040247)
- Tyrosine kinase inhibitors with diarylamine scaffolds such as gefitinib (FS200036), lapatinib (FS200039), and nilotinib (FS200045).
- Advanced Glycosylation Endproducts (AGEs), useful for understanding aging-related protein modification, include CML (FS810003), and pentosidine (FS810006).
- Organoselenium compounds useful as free-radical scavenging antioxidants (FS000075- FS000079).
Discounts, Rebates and Bargains
Focus Synthesis offers a number of incentives that can help you to reduce costs, as outlined below. These incentives are available for a limited time only, and may be discontinued without notice. Please inquire for additional details.
- The Bargains subcatalog includes popular items at prices that are competitive with other catalog, and rare items priced at less than $99 per gram that are not found in other chemical catalogs. Click here to see the Bargains subcatalog, including chemical structures.
- The "Less than $500" catalog is provided to assist customers who have a $500 limit on purchases.
- Generous volume discounting is available for most Special Order compounds and many stock items.
- We offer discounts for the purchase of 20 or more different items in one order. Please Inquire.
Synthon Design Services
Focus Synthesis now offers confidential building block design services to help meet your specific requirements for
diversity and property space coverage in medicinal and high-throughput chemistry. The synthetic intermediates made
through Synthon Design ServicesSM, known as SDS Building BlocksTM, will be substantially distinct
from commercially available building blocks. All rights to the molecules and their method of synthesis will be made
available to you, and your will be able to specify a period of exclusivity (no listing in the Focus Synthesis catalog)
ranging from 6 months to 6 years. Differentiation from commercial building blocks will be based on Rare and Unique
SubstructuresTM, ultrarare substructures (RubySynthonsTM), exotic heterocycles
(RubyScaffoldsTM), rare molecular graphs (RubyShapesTM), and Cheminformatic Gap FillersTM.
More detailed descriptions of the corresponding catalog products can be found on the
About Page.
A more focused service, also requiring the protection of a nondisclosure agreement, would provide the most useful diversity by identify building blocks that are distinct relative to your corporate compound collection as well as commercial databases. SDS Building BlocksTM will be designed to meet other specifications that you define, such as PSA, ClogP, FW, EA, type of functionality, ring system, complexity, rule-of-five, etc.
Care will be taken to ensure synthetic accessibility. If warranted, in-house trial runs of key synthetic steps can be carried out in house on small (~100 mg) scales to better determine feasibility. In-house custom synthesis of larger quantities (up to 20 grams) by Focus Synthesis will be provided as an option. Part of the design cost will be discounted if you choose Focus Synthesis to synthesize the SDS blocksTM.
Catalogs for Downloading (Updated July 22, 2010)
Download the Focus Synthesis catalog in the format of your choice:
Complete Catalogs
Items In Stock
- In Stock items only (July 22, 2010) in Microsoft Excel (.xls) format
- In Stock items only (July 22, 2010) in .pdf format
- In Stock items only (July 22, 2010) in .sdf format
- In Stock items only (July 22, 2010) in .db format (compressed file downloadable in .zip format)
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