The price of large diversity voids in a corporate compound collection can literally be billions of dollars--think of losing out to a competitor who files a patent application first, or experiencing failure in Phase III or IV because a more suitable candidate series was unavailable. When a lack of drug candidate choices prevents development of a less toxic alternative, the price of inadequate diversity is also measured in human lives.

Whether you are making series of molecules through conventional medicinal or high-throughput chemistry, and whether making broad or focused libraries, voids in precursor chemical property space become larger, more extensive voids in drug candidate property space. Ensuring synthon and building block diversity and property space coverage is key to keeping your drug pipeline full of healthy candidates.

Focus Synthesis offers synthons, building blocks, research chemicals, and exotic heterocycles that are optimized for drug discovery using cheminformatics-based design. In addition to being a research chemical supplier specializing in drug candidate intermediates and other organic chemicals, Focus Synthesis also provides custom synthesis outsourcing, in-house custom chemistry, and proprietary design services.

To help you build truly diverse, robust corporate compound collections, Focus Synthesis uses chemoinformatics to design "drugable" synthons and building blocks that are as distinct as possible from the offerings of other vendors. The rare chemicals offered by Focus Synthesis fill the gaps in chemical catalog space.



Several examples of Focus Synthesis products are shown below, with the rare substructures highlighted in red. Few if any molecules in the Available Chemical Directory (Elsevier-MDL) containing these substructures are available outside of Focus Synthesis. A complete product listing can be found by clicking here: Products page.


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