Weinreb amides (N-methyl-N-methoxyamides) can be combined with carbanions (alkyllthiums, aryllthiums, and Grignard reagents) to form ketones without any further reaction. The reaction is compatible with Boc-amine and Cbz-amine groups, allowing synthesis of protected amino ketones. See the following URL for more details: http://www.organic-chemistry.org/namedreactions/weinreb-ketone-synthesis.shtm
*Note concerning Special Order chemicals: these are made to order
with a typical lead time of 6 weeks. |
Minimum order sizes apply
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